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KMID : 1143420210140070370
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Public Health Weekly Report
2021 Volume.14 No. 7 p.370 ~ p.377
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Serotype Distribution and Antimicrobial Susceptibility of Non-Streptococcus of Non-Invasive Streptococcus pneumoniae Among Children with Pneumonia in Korea, 2018-2019
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Kim So-Hyeon
Kim Dong-Hyeok
Hwang Kyu-Jam
Lee Chae-Young
Yoo Jae-Il
Jung Sang-Oun
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Abstract
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S. pneumoniae is a causative pathogen that accounts for 25-40% of community acquired pneumonia (CAP) and which
causes non-invasive infections such as otitis media and sinusitis and invasive diseases including bacteremia and meningitis. The pneumococcal vaccine prevents infection caused by a major serotype that is highly associated with infectious diseases among 94 serotypes of pneumococcal. Recently, a national pneumococcal vaccination program caused a serotype replacement phenomenon in which infection with the vaccine serotype decreased and the disease caused by nonvaccinated serotypes not included in the vaccine increased.
This paper analyzed the characteristics of 84 strains of S. pneumoniae from sputum specimens collected through the
pediatric pneumonia monitoring project from 2018 to 2019. The distribution of age showed 0-3 years old (73%), 4-6 years
old (16%), 7-9 years old (6%), 10 years old or older (1%) and unknown (4%). Serotype distribution analysis showed that the major serotypes were 23A (14.3%), 6C (13.1%), 10A (8.3%), 15B (8.3%), 23B (8.3%), 35B (8.3%), 34 (7.1%), followed by 19F (6.0%), and these serotypes accounted for 73.8% of the total with 62 strains. A total of 65.5% (55 isolates) were nonvaccinated serotypes, and 16.0% (17 isolates) were included in the PPSV23 vaccine. The serotypes included in the PCV10 vaccine and PCV13 vaccine were 6.0% (5 isolates) and 4.8% (4 isolates), respectively. As a result of 16 antibiotic
susceptibility tests by broth microdilution method, the resistance rates to Azithromycin, Cefaclor, Cefuroxime, lindamycin,
Erythromycin, and Tetracycline were 77.4%, 82.1%, 77.4%, 61.9%, 77.4%, and 66.7%, respectively. Multi-drug resistant
bacteria that were simultaneously resistant to three or more antibiotic classes was 74 strains (88.1%), respectively.
Therefore, this paper concluded that continuous serotype analysis and antibiotic resistance monitoring is necessary for
evaluating pneumococcal vaccine efficacy and management to S. pneumoniae infection.
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KEYWORD
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Streptococcus pneumoniae, Vaccine, Serotype, Antibiotics resistance
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